In 1964 Peretti decided to embark on a new career path as a fashion model. After having spent her first couple of years in Barcelona, Spain, she followed Wilhelmina Modeling Agency's suggestion to move to New York Cityin 1968. ‘Elsa Peretti in Bunny Costume’ is a lasting image of the 1970s by Helmut Newton. While modelling in Manhattan, Peretti began creating new jewelry styles for a handful of fashion designers including Giorgio di Sant' Angelo and Halston. She was initially inspired by a silver flower vase she had found at a flea market. Peretti became involved in the drug scene around Studio 54, but was sober by 1971. By the time Peretti joined Tiffany & Co. as an independent designer, she had already received the 1971 Coty Award and had her first appearance in Vogue magazine. In 1972 Bloomingdale's, one of New York's landmark shopping stores, opened a dedicated Peretti boutique. In 1974 Peretti joined Tiffany & Co. In 2012 Tiffany and Peretti extended their partnership for 20 years.